NeuN positive CA1 hippocampal neurons after sham operated rat brain.
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NeuN positive CA1 hippocampal neurons after 4 vessel occlusion (4VO)-induced global ischemia in vivo.
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Dr. Park’s lab is currently investigating mechanisms of neuronal death signaling that occur during cerebral ischemia (stroke) and neurodegenerative diseases (e.g. Parkinson’s and Alzheimer’s disease). Her team is particularly interested in the dynamics of the mitochondrial protein Bcl-xL. Bcl-xL is known as a pro-survival protein, but a cleaved form of Bcl-xL, ΔN-Bcl-xL, accumulates during neurotoxic stimulation, triggering neuronal death. Therefore, regulation of Bcl-xL and ΔN-Bcl-xL is critical to maintain normal neurophysiology. In addition, Dr. Park’s team is developing strategies to enhance brain development and to protect the brain against neurotoxic injury using nutritional, genetic, and pharmacological approaches.
Key Words
Cerebral ischemia (stroke), mitochondria, apoptosis, Bcl2 family protein, redox signaling, neurogenesis.
Selected Publications
Han-A Park, Pawel Licznerski, Nelli Mnatsakanyan, Yulong Niu, Silvio Sacchetti, Jing Wu, Brian M. Polster, Kambiz N. Alavian, and Elizabeth A. Jonas. Inhibition of Bcl-xL prevents pro-death actions ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity. Cell Death & Differentiation. 24, 1963-1974 (2017)
[impact factor: 8.18]
Han-A Park, Pawel Licznerski, Kambiz N. Alavian, Marya Shanabrough, and Elizabeth A. Jonas. Bcl-xL is necessary for neurite outgrowth in hippocampal neurons. Antioxidants & Redox Signaling. 22, 93-108 (2015)
[impact factor: 7.4]
Han-A Park, Natalia Kubicki, Surya Gnyawali, Yuk Cheung Chen, Sashwati Roy, Savita Khanna, and Chandan K. Sen. Natural vitamin E α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1. Stroke 42, 2308-2314 (2011)
[impact factor: 5.72]
Han-A Park, Savita Khanna, Cameron Rink, Surya Gnyawali, Sashwati Roy, and Chandan K. Sen. Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway. Cell Death & Differentiation. 16, 1167-1179 (2009)
[impact factor: 8.18]
Full List of Publications
Key Words
Cerebral ischemia (stroke), mitochondria, apoptosis, Bcl2 family protein, redox signaling, neurogenesis.
Selected Publications
Han-A Park, Pawel Licznerski, Nelli Mnatsakanyan, Yulong Niu, Silvio Sacchetti, Jing Wu, Brian M. Polster, Kambiz N. Alavian, and Elizabeth A. Jonas. Inhibition of Bcl-xL prevents pro-death actions ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity. Cell Death & Differentiation. 24, 1963-1974 (2017)
[impact factor: 8.18]
Han-A Park, Pawel Licznerski, Kambiz N. Alavian, Marya Shanabrough, and Elizabeth A. Jonas. Bcl-xL is necessary for neurite outgrowth in hippocampal neurons. Antioxidants & Redox Signaling. 22, 93-108 (2015)
[impact factor: 7.4]
Han-A Park, Natalia Kubicki, Surya Gnyawali, Yuk Cheung Chen, Sashwati Roy, Savita Khanna, and Chandan K. Sen. Natural vitamin E α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1. Stroke 42, 2308-2314 (2011)
[impact factor: 5.72]
Han-A Park, Savita Khanna, Cameron Rink, Surya Gnyawali, Sashwati Roy, and Chandan K. Sen. Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway. Cell Death & Differentiation. 16, 1167-1179 (2009)
[impact factor: 8.18]
Full List of Publications
